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GenAP is a Canadian platform that provides Galaxy instances across different Canadian HPC centers. Having more that 7 TB of reference genomes, replicating this data in all HPC centers becomes expensive and hard to keep in synch. Cern VM files system (CVMFS) allow us to centralize the provisioning, replicate the data and distribute genome references on demand. In CVMFS the local machine only imports the genomes necessary for the job being run allowing the use of a minimal storage by the HCP centers.