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Wednesday, June 29 • 3:15pm - 4:30pm
P08: COMBAT TB Explorer, a TB data exploration workbench

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Poster    doi:10.7490/f1000research.1112402.1


Peter van Heusden, Ziphozake Mashologu, Alan Christoffels, South African National Bioinformatics Institute

Tuberculosis (TB), an infectious disease caused by the Mycobacterium tuberculosis, ranks as one of the leading causes of death worldwide, with WHO recording 9.6 people falling ill with 1.5 million deaths in 2014. This disease burden has arguably been matched with continued increase in genomic, transcriptomic and proteomic data for Mycobacterium tuberculosis as a result of NGS technologies. This continued expansion of data is exemplified by the growth of data repositories such as the tuberculosis database (TBDB)  and the pathosystems resource integrated center (PATRICBRC). Unfortunately, these resources only present pre-computed data and do not provide the computational toolkit for biomedical researchers to analyze their own data. We have created the COMBAT TB Explorer, a Galaxy-based environment for annotating and exploring M. tuberculosis sequence data. COMBAT TB Explorer currently combines a genomic variant calling pipeline with a web based tool for exploring the relationship between variants and known annotation and allows the user to perform geneset enrichment analysis.

avatar for Ziphozake Mashologu

Ziphozake Mashologu

Developer, UWC - South African National Bioinformatics Institute
I am part of the Software Development Team at SANBI - University of the Western Cape. I've been involved in building web and mobile applications for nearly a decade and is have high interest in the Galaxy project.

Attendees (5)